Summaries by Inventor Pferdehirt, Lara

Stem cells that produce decorin
Guilak, Farshid ; Pferdehirt, Lara
T-019343

— Using CRISPR-based gene editing, decorin was inserted downstream of Smad7 to create autoregulated stem cells that can produce decorin. As Smad7 is activated during TGF-beta signaling, the stems cells produce decorin in response to TGF-beta. Decorin is a key modulator of extracellular matrix assembly…